Publications
The following is a table of publications related to mannitol and its use as a bronchial challenge agent. This list is updated regularly, with publications appearing in date order.
Most of these papers have abstracts that are accessible through PubMed.
Mannitol as a Bronchial Provocation Test:
Authors |
Title |
Reference |
Wood LG, Powell H, Gibson PG. |
Mannitol challenge for assessment of airway responsiveness, airwayinflammation and inflammatory phenotype in asthma |
Clinical and Experimental Allergy. 2009; 40:232-241 Clinical Study
|
Miedinger D, Mosimann N, Meier R, et al. |
Asthma tests in the assessment of military conscripts |
Clinical and Experimental Allergy 2009; 40: 224-231 Clinical Study |
Anderson SD, Brannan JD. |
Bronchial provocation testing and collection of sputum with inhaled mannitol |
Clinical and Experimental Allergy 2009; 1-4 Editorial[K1] |
Cockcroft D, Davis B. |
Direct and indirect challenges in the clinical assessment of asthma |
Ann Allergy Asthma Immunol. 2009 Nov;103(5):363-9. Review |
Brannan JD, Porsbjerg C, Anderson SD |
Inhaled mannitol as a test for bronchial hyperresponsiveness |
Expert Rev Resp Med 2009; 3(5): 457-468[K4] Review |
Porsbjerg C, Backer V, Joos G, et al. |
Current and future use of the mannitol bronchial challenge in everyday clinical practice |
Clin Resp J 2009; 3: 189-197 |
Sverrild A, Porsbjerg C, Thomsen SF, Backer V.J. |
Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study |
Allergy Clin Immunol. 2009 Nov; 124:928-32[K3] Clinical Study |
Spector, S. |
Use of Mannitol Inhalation Challenge in Assessment of Cough |
Lung, 2009 Sep 16 Epub ahead of print. Review[K2] |
Sverrild A, Porsbjerg C, Thomsen SF, Backer V. |
Diagnostic properties of inhaled mannitol in the diagnosis of asthma: A population study. |
J Allergy Clin Immunol. 2009 Aug 7. |
Porsbjerg C, Lund TK, Pedersen L, Backer V. |
Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO |
J Asthma. 2009 Aug;46(6):606-12. |
Horsman TA, Duke RK, Davenport PW. |
Airway response to mannitol challenge in asthmatic children using impulse oscillometry. |
J Asthma. 2009 Aug;46(6):600-3. |
Kersten ET, Driessen JM, van der Berg JD, Thio BJ. |
Mannitol and exercise challenge test in asthmatic children |
Pediatr Pulmonol. 2009 Jul;44(7):655-61. |
Cockcroft DW, Davis BE. |
Diagnostic and therapeutic value of airway challenges in asthma |
Curr Allergy Asthma Rep. 2009 May;9(3):247-53. Review |
Lund TK, Pedersen L, Anderson SD, Sverrild A, Backer V. |
Are asthma like symptoms in elite athletes associated with classical features of asthma. |
Br J Sports Med. 2009 Feb 6 |
O'Byrne PM, Gauvreau GM, Brannan JD. |
Provoked models of asthma: what have we learnt? |
Clin Exp Allergy. 2009 Feb;39(2):181-92. Review |
Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group. |
Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma |
Respir Res. 2009 Jan 23;10:4. |
Muñoz PA, Gómez FP, Manrique HA, Roca J, Barberà JA, Young IH, Anderson SD, Rodríguez-Roisin R. |
Pulmonary gas exchangeresponse to exercise- and mannitol-induced bronchoconstriction in mild asthma |
J Appl Physiol. 2008 Nov;105(5):1477-85. Epub 2008 Aug 28 |
Rundell KW, Slee JB. |
Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes |
J Allergy Clin Immunol. 2008 Aug;122(2):238-46; quiz 247-8. Review. |
Anderson SD. |
Provocation challenges to help diagnose and monitor asthma: exercise, methacholine, adenosine and mannitol. |
Curr Opin Pulm Med. 2008 Jan;14(1):39-45. Review |
Porsbjerg C, Brannan JD, Anderson SD, Backer V. |
Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. |
Clin Exp Allergy. 2008 Jan;38(1):43-50. Epub 2007 Nov 19 |
Schafroth Török S, Leuppi JD. |
Bronchial hyperresponsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease |
Swiss Med Wkly. 2007 Jul 14;137(27-28):385-91. Review. |
Miedinger D, Chhajed PN, Tamm M, Stolz D, Surber C, Leuppi JD. |
Diagnostic tests for asthma in firefighters |
Chest. 2007 Jun;131(6):1760-7. Epub 2007 Mar 30. |
Stolz D, Anderson SD, Gysin C, Miedinger D, Surber C, Tamm M, Leuppi JD. |
Airway reactivity to inhaled mannitol in cigarette smokers: a longitudinal study |
Respir Med. 2007 Jul;101(7):1470-6. Epub 2007 Feb 26. |
Porsbjerg C, Rasmussen L, Thomsen SF, Brannan JD, Anderson SD, Backer V. |
Response to mannitol in asymptomatic subjects with airway hyper-responsiveness to methacholine. |
Clin Exp Allergy. 2007 Jan;37(1):22-8. |
Haney S, Hancox RJ. |
Recovery from bronchoconstriction and bronchodilator tolerance |
Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):181-96. Review. |
Gulliksson M, Palmberg L, Nilsson G, Ahlstedt S, Kumlin M. |
Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. |
Allergy. 2006 Dec;61(12):1473-9. |
Menzies D, Nair A, Lipworth BJ. |
Non-invasive measurement of airway inflammation in asthma |
J Asthma. 2006 Aug;43(6):407-15. Review. |
Brannan J.D,1, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M |
Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing |
Eur Respir J 2006; 27: 944—950 |
Sak I, Kurzawa R, Nowosielska A. |
Bronchial challenges in asthma control |
Przegl Lek. 2005;62(12):1488-93. Review. Polish |
Anderson SD |
Best indicators of asthma control; Asthma biomarkers including spirometry |
AAAI 2006, Session 5533 workshop presentation |
Stolz D, Gysin C, Miedinger D, Tandjung R, Surber C, Tamm M, Leuppi J |
Airway responsiveness to inhaled mannitol is increased in smokers and decreases after short term smoking cessation |
CHEST / 128 / 4 / October, 2005 Supplement |
Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B and the Aridol Study Group |
The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline |
Respiratory Research 2005, 6:144 |
Carlson KH; taskforce on recognising and diagnosing exercise related asthma, respiratory and allergic disorders in sport.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. |
Evidence based recommendations for the diagnosis of exercise induced asthma in athletes. |
Carlsen K-H, Delgado L, Del Giacco S, Eds. Eur Respir Mon: European Respiratory Society, 2005;10(33);Chpt 10 |
Anderson SD, Bruscasco V, Haahtela T, Popov T.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. |
Criteria for diagnosis of asthma, EIB and AHR for athletes: lessons from the Olympic Games |
Carlsen K-H, Delgado L, Del Giacco S,Eds. Eur Respir Mon: European Respiratory Society, 2005; 10(33); Chpt 6 |
Koskela H, Martens R, Brannan JD, Anderson SD, Leuppi JD, Chan H-K. |
Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects |
Respirology (2005) 10, 442—448 |
Anderson S.D, Brannan J.D, Koskela H, Leuppi J.D |
Monitoring Airway Hyperresponsiveness: Indirect Stimuli—Exercise, Hypertonic Saline, Mannitol, and AMP |
Monitoring Asthma ed. Gibson PG; Taylor and Francis Group, Boca Raton USA |
Anderson S.D, Brannan J.D, Freed-Martens R.H, and The Aridol Study Group. |
Bronchial provocation using inhaled mannitol - a phase 3 trial of paediatric asthmatics and non-asthmatics |
ATS 2005 Abstract #955218 |
Brannan J.D, Anderson S.D, Freed-Martens R.H, and The Aridol Study Group. |
Bronchial provocation using inhaled mannitol - a phase 3 trial of adult asthmatics and non-asthmatics |
ATS 2005 Abstract #953009 |
Freed-Martens R, Anderson S.D, Brannan J.D, Aridol study group |
Effect of treatment on recovery of FEV1 to baseline after a mannitol challenge: a phase 3 study |
Australian New Zealand Soc Resp Sci ASM 2005 Abst. |
Anderson S.D |
Bronchoprovocation Challenges: The How To's |
Session 4701: AAAAI San Antonio Texas 2005 (Pres.) |
Anderson S.D |
Theory and Rationale for bronchial provocation studies in asthma |
Session 2714: AAAAI San Antonio Texas 2005 (Pres.) |
Anderson S.D, Brannan J.D, Koskela H, Freed-Martens R, Leuppi J.D, Holzer K, Lipworth B, Currie K, Sue-Chu M, Perry C.P. |
Provoking Dose Of Mannitol To Assess Airway Hyperresponsiveness In Asthma: A Retrospective Analysis |
Abstract No: 1460 AAAAI ASM 2005 (Poster) |
Leuppi J.D, Tandjung R, Anderson S.D, Stolz M.H, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Knoblauch A, Andersson M, Greiff L, Chan H-K, Tamm M |
Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept |
Pulmonary Pharmacology & Therapeutics 18 (2005) 83—88 |
Barben J, Riedler J |
Measurement of Bronchial Responsiveness in Children |
Paed Pulm Function Testing. Prog Respir Res. Basel, Karger, 2005, vol 33, pp 125—136 |
Tandjung R, Anderson S.D, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Tamm M, Leuppi J.D |
Prediction of Treatment-Response to Inhaled Corticosteroids by Mannitol-Challenge Test in COPD |
Poster 502 ATS 2004 |
Lee DK |
Airway hyperresponsiveness to bronchial mannitol: where do we go from here? |
Chest . 2004 Jul;126(1):318-9; author reply 319-20. |
D. Jaccard-Stolz, M. Tamm, S.D. Anderson, C. Suber, J.D. Leuppi |
Bronchial Hyperreactivity to Mannitol before and after Smoking Cessation |
Poster K28 ATS 2004 |
Koskela H.O, Hyv?rinen L, Brannan J.D, Chan H-K, Anderson S.D. |
Coughing During Mannitol Challenge Is Associated With Asthma |
Chest 2004; 125:1985—1992 |
Currie G.P, Jackson C.M, Lipworth B.J |
Does Bronchial Hyperresponsiveness in Asthma Matter? |
J of Asthma Vol. 41, 3, pp. 247—258, 2004 |
Gulliksson M, Brannan J.D, Anderson S.D, Seale P.J, Delin I, Kumlin M. |
Inhibition of the airway response to mannitol with either eformoterol or sodium cromoglycate (SCG) does not alter leukotriene release in asthmatic subjects |
Eur Resp J, 2004; 24: 443s ;P2735 |
Leuppi J.D, Tandjung R, Anderson S.D, Brutsche M.H, Surber C, Bingisser R, Perruchoud A.P, Tamm M |
An indirect bronchoprovocation challenge test using the dry powder Mannitol in mild COPD-patients |
Poster ERS Vienna 2003 |
Brannan JD, Anderson SD, Perry CP, Kippelen P, Freed R, Holzer K, Sue-Chu M |
Bronchial Provocation Tests using a Dry Powder of Mannitol in Asthmatic and Healthy Subjects with Normal Spirometry |
VIIth IOC World Congress on Sports Science Athens, Greece October 2003 |
Joos G.F (Chairman), O'Connor B (Co-Chairman), Anderson S.D, Chung F, Cockcroft D.W, Dahlen B, DiMaria G, Foresi A, Hargreave F.E, Holgate S.T, Inman M, L?tvall J, Magnussen H, Polosa R, Postma D.S, Riedler J. |
ERS Task Force Report: Indirect airway challenges |
Eur Respir J 2003; 21: 1050—1068 |
Barben J, Roberts, Chew N, Carlin J.B, Robertson C.F |
Repeatability of Bronchial Responsiveness to Mannitol Dry Powder in Children With Asthma |
Pediatric Pulmonology 36:490—494 (2003) |
Brannan JD |
Inhaled Mannitol ; A new Bronchial Provocation Test to assess the presence and severity of asthma. |
RT International, Fall 2003: 29-3142. |
Lee DK, Haggart K, Currie GP, Anderson SD, Lipworth BJ. |
The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis. |
Br J Clin Pharmacol 2003; 55(6):639-642. |
Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M. |
Evidence of mast cell activation and leukotriene release after mannitol inhalation. |
Eur Respir J 2003; 22(3):491-496 |
Koskela H.O; Hyv?rinen L; Brannan J.D; Chan H.K; Anderson S.D |
Responsiveness to Three Bronchial Provocation Tests in Patients With Asthma |
Chest 2003; 124:2171—2177 |
Koskela HO, Hyv?rinen L, Brannan JD, Chan H-K, Anderson SD. |
Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. |
Chest 2003; 124(4):1341-1349. |
Currie GP, Haggart K, Brannan JD, Lee DKC, Anderson SD, Lipworth BJ. |
Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate. |
Allergy 2003 58:762-766 |
Currie GP, Haggart K, Lee DKC, Fowler SJ, Wilson AM, Brannan JD, Anderson SD, Lipworth BJ. |
Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. |
Clin Exp Allergy 2003; 33:783-788. |
Anderson SD, Brannan JD. |
Methods for 'indirect' challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols. |
Clin Rev Allergy Immunol 2003; 24: 27-54. |
Holzer K, Anderson SD, Chan H-K, Douglass J. |
Mannitol as a challenge to identify exercise-induced bronchoconstriction in elite athletes. |
Am J Respir Crit Care Med 2003; 167: 534-537. |
Holzer K, Anderson SD, Douglass J. |
Exercise in Elite Summer Athletes: challenges for diagnosis. |
J Allergy Clin Immunol 2002; 110: 374-380. |
Anderson SD, Brannan JD, Chan HK. |
Use of aerosols for bronchial provocation testing in the laboratory: Where we have been and where we are going. |
J Aerosol Med 2002;15(3):313-324. |
Leuppi JD, Brannan JD, Anderson SD. |
Bronchial provocation tests: The rationale for using inhaled mannitol as a test for airway hyperresponsiveness. |
Swiss Medical Weekly 2002; 132:151-158. |
Brannan JD, Koskela H, Anderson SD, Chan H-K. |
Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. |
Respirology 2002; 7(1):37-44. |
Leuppi JD. Salome CM, Jenkins CR, Koskela H, Anderson SD, Andersson M, Chan H-K, Woolcock AJ. |
Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. |
Eur Respir J 2001; 18(3):444-450. |
Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP. |
Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. |
Am J Respir Crit Care Med 2001; 163: 1420-1425. |
H?gman M, Lúdviksdóttir D,Anderson SD, George S, Hakansson L, Chan HK, Meril?inen,P, Hedenstr?m H. |
Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatic and healthy subjects. |
Respiration Physiology 2001; 124:141-150. |
Leuppi JD. Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan H-K, Woolcock AJ. |
Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. |
Am J Respir Crit Care Med2001; 163:406-412. |
Koskela H, Di Sciascio M, Anderson SD, Andersson M, Chan H-K, GadallaS, Katelaris C. |
Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement. |
Clin Exp Allergy 2000; 30(11):1628-1636. |
Brannan JD, Anderson SD, Freed R, Leuppi JD, Koskela H, Chan H-K. |
Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects. |
Am J Respir Crit Care Med 2000; 161; 2096-2099. |
Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL. |
Inhaled mannitol identifies methacholine-responsive children with current asthma. |
Pediatr Pulmonol 2000; 29:291-298. |
Brannan JD, Koskela H, Anderson SD, Chew N. |
Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. |
Am J Respir Crit Care Med, 1998: 158:1120-1126. |
Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR. |
A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. |
Am J Respir Crit Care Med 1997; 156: 758-765. |